Understanding how DART study design reveals biological mechanisms.
Selecting the correct developmental and reproductive toxicology (DART) study is essential for generating meaningful nonclinical safety data. Each study type captures a distinct developmental window, and choosing between EFD, FEED, PPND, and juvenile studies requires a clear understanding of developmental biology, mechanistic drivers, and regulatory expectations.
In this webinar, Inotiv scientists Johnathan Furr and AtLee Watson outline how scientific rationale, developmental timing, and study design come together to ensure the right DART study is selected for your program. They will also highlight practical considerations for multigeneration studies such as OECD 421/422 and OECD 443—critical for chemicals, food products, and pharmaceuticals where exposure spans multiple reproductive and developmental stages.
Watch to gain deeper scientific insight into how DART study selection shapes nonclinical strategy, strengthens nonclinical packages, and reveals mechanisms that inform reproductive and pediatric risk.
Key learning objectives:
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Understand how distinct DART study types (EFD, FEED, PPND, juvenile) capture different developmental windows and mechanistic endpoints.
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Learn how biological mechanisms and regulatory objectives guide selection of the appropriate DART study.
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Explore how juvenile studies provide unique insight into pediatric risk and developmental vulnerability.
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Review considerations for multigeneration studies (OECD 421/422/443) and how they support chemical, food, and pharmaceutical safety evaluation.
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