Analysis of metabolites formed in reaction phenotyping assays for low clearance compounds provides additional sensitivity for estimating CYP contribution to drug metabolism. Combining High Resolution Mass Spectrometry and software-aided metabolite assessment provides a more efficient and informative approach for enzyme phenotyping of drug metabolizing enzymes. This approach may be incorporated when using either recombinant enzymes, subcellular fractions, suspended hepatocytes, and long-term hepatocyte co-cultures.
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