Microscopic examination of the nervous system is a critical aspect of nonclinical general toxicity studies. To ensure consistent and accurate data collection, we developed a standardized canine brain trimming protocol that utilizes external anatomic landmarks. This approach is designed to be easily implemented by trained laboratory staff and guarantees the reliable capture of key neuroanatomic regions for evaluation in nonclinical toxicity assessments. Our research was presented in a poster, “Using Anatomic Landmarks for Reliable Canine Brain Sampling in Nonclinical General Toxicity Studies,” at the August 2024 European Society of Toxicologic Pathology.
Download your copy of the poster to learn more about:
- Which external anatomic landmarks of the brain were utilized
- Results of the sectioning using external landmarks
