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The B-NDG mouse model lacks mature B cells, T cells, NK cells and has a deficiency in cytokine signaling. This triple immunodeficiency enhances tumor cell acceptance and results in decreased leakiness as compared to other SCID models. There is also a high humanization capability for human immune cell engraftment with minimal rejection. Herein we describe results for several tumor model comparison studies between the B-NDG mouse model and other commonly used immunodeficient models.
