Reevaluation of Age-Related Behavioral Phenotypes in the SAMP8 Mouse Model of Senescence
The senescence-accelerated mouse (SAMP8) is widely used to study mechanisms of aging-related cognitive decline, sarcopenia, and neurodegenerative disease. However, after nearly 40 years of colony maintenance, questions have emerged about possible genetic drift and whether hallmark phenotypes remain stable. Inotiv researchers conducted a comprehensive behavioral reevaluation comparing SAMP8 and SAMR1 control mice to confirm the model’s continued translational relevance.
Explore this poster to learn about:
- Current behavioral and cognitive outcomes in SAMP8 mice versus SAMR1 controls
- Which hallmark phenotypes—motor deficits, altered anxiety, and impaired memory—remain robust
- Newly observed differences suggesting phenotype drift in long-term colonies
- The importance of routine model validation for reliable aging and CNS research
Click here to download this scientific poster!
