Inflammatory bowel disease (IBD) is defined as an idiopathic chronic relapsing and remitting disorder of the small intestine and/or colon. Treatment of IBD in patients is complicated by the heterogenous presentation of development and disease symptoms. Although there is no single animal model that recapitulates the human disease, there are several models that nicely demonstrate the key clinical and histopathological aspects of disease.
Watch the presentation now to learn:
- Key features of live phase and histopathological disease parameters in various colitis models including dextran sulfate salt (DSS) induced colitis models, adoptive T cell transfer models, Il10 knockout (KO) models, MDR1a KO models.
- Advantages and limitations of the current preclinical IBD mouse models.
- Guidance selecting the most biologically relevant IBD model for drug target development.
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