Evaluate spontaneous cardiac lesions in research-colony macaques.
Cardiac findings are common in nonhuman primates and can overlap with potential test-article effects. Understanding background incidence is essential for accurate interpretation in cardiovascular and general toxicology studies.
This three-year survey evaluated 405 rhesus and cynomolgus macaques submitted for diagnostic necropsy. Over one third had at least one cardiac microscopic finding, with species- and age-related patterns. Common lesions included mononuclear infiltrates, cardiomyocyte degeneration/necrosis, fibrosis, and karyomegaly.
This study demonstrates how colony-specific baseline data support interpretation of cardiac findings in NHP studies.
What You’ll Learn from This Scientific Poster:
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How cardiac lesion incidence varies by species and age
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How to differentiate spontaneous myocarditis and cardiomyopathy from test-article effects
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How Trypanosoma cruzi infection appears histologically in NHPs
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How background cardiac pathology informs study design and interpretation
Download the Scientific Poster to explore how NHP cardiac HCD support cardiovascular safety assessment.
