The B-NDG model is a knockout mouse with an ultra-immunodeficient phenotype. The model was generated by Biocytogen by deleting the IL2rg gene from NOD-scid mice. Prkdc (protein kinase DNA-activated catalytic) null scid mutation is characterized by significantly deficient of functional T cells and B cells. The common gamma chain gene (IL2RG) deletion results in a lack of functional receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21, which results in the lack of functional NK cells.
In the B2m model, the B2m gene is fused in the FcRn gene while the endogenous murine B2m gene is knocked out. This mouse combines the B-NDG mouse background with the absence of the MHC class I molecule β2m and shows no difference in the metabolism
of IgG drugs in mice compared with wild-type mice.
This model is effective against GvHD effects.
For the hIL15 model, the human IL15 gene was inserted after the 5’UTR of the mouse IL15, so that this mouse expresses the
human IL15 cytokine. This mouse combines a B-NDG mouse background and expresses human IL15 cytokine. It will become a
suitable animal model to investigate development and function of human NK cells.
Click on each model to learn more about its creation, characterization, and benefits. Then fill out the form to request more information and to be notified when these models are available in your geographic region for your research.
The B-NDG models portfolio:
- B-NDG mouse model
Status: Inventory is currently available globally (US, Europe, and UK) - B-NDG humanized IL15 mouse model
Status: Inventory is currently available globally (US, Europe, and UK) - B-NDG B2m Plus mouse model
Status: Inventory is currently available globally (US, Europe, and UK)
