Evaluate retinal health in refreshed ICR mouse colonies.
Retinal degeneration associated with the pde6b mutation historically affected up to 80% of ICR mice, complicating ocular toxicity interpretation. A refreshed U.S. colony—derived from mutation-free stock—was evaluated to confirm elimination of this background lesion.
Genotyping and microscopic evaluation showed that nearly all refreshed-colony animals were wild type, with no retinal degeneration observed. In contrast, discontinued-colony animals showed moderate bilateral retinal atrophy consistent with the pde6b mutation.
This study demonstrates how colony refresh and genetic screening improve model reliability for ocular safety assessment.
What You’ll Learn from This Scientific Poster:
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How the pde6b mutation drives retinal degeneration in ICR mice
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How refreshed colonies eliminate this confounding background lesion
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How genotype and histopathology confirm improved model quality
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How refined colonies support clearer interpretation of ocular findings
Download the Scientific Poster to explore how refreshed ICR colonies strengthen ocular toxicity studies.
