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Osteosarcoma (OS) is associated with a poor prognosis, as it is often resistant to chemotherapy and tends to metastasize to the lungs.
Researchers at the Chongqing Medical University and the University of Chicago Medical Center ran a study to test OS cell proliferation and tumor growth in Inotiv’s athymic nude mouse model (Hsd:Athymic Nude-Foxn1nu) to better understand the molecular and cell-signaling pathways of OS.
This article summarizes their work published in Current Cancer Drug Targets and discusses this innovative use of the Hsd:Athymic Nude-Foxn1nu mouse as an orthotopic tumor model in oncology research.
Download today and you’ll learn about:
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The innovative use athymic nude mice as an orthotopic tumor model
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Target genes that may mediate a signaling pathway in osteosarcoma
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How tumor growth differed with the forced expression of dnNotch1 mutant.
