A multidisciplinary approach to mapping immune responses and signaling pathways using the TCT colitis model.
Preclinical Inflammatory Bowel Disease (IBD) research is often stalled by "one-size-fits-all" approaches that fail to account for complex disease phenotypes. To move discovery forward, we must look beyond standard histopathology and map the actual signaling pathways driving the disease.
Our recent eBook uses the adoptive T-cell transfer (TCT) colitis model to demonstrate how integrated, multi-omic data clarifies these complexities:
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The "Wiring Diagram" of Disease: Global proteomics transforms animal models into transparent systems by connecting disease phenotypes directly to drug target pathways.
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Precision Localization: Our AI-driven digital pathology segments tissue into distinct anatomical regions to pinpoint exactly where biomarker changes occur.
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High-Resolution Spatial Biology: We integrate spatial transcriptomics to visualize RNA abundance across the tissue. This allows you to assess cellular responses and pathway activation at the RNA level, providing a comprehensive view of therapeutic efficacy.
By combining these complementary tools, you can quantitatively verify pathway-level changes and gain a nuanced, 360-degree understanding of your therapeutic’s mechanism of action.
Complete the form to view the ebook with the option to speak to an expert.
