Download your copy today
Download your copy todayJuvenile toxicology is complicated due to the dynamic anatomic and physiological changes that occur during growth and development of an individual. Non-clinical juvenile toxicity studies are logistically complicated due to their size, the number, diversity and interdependence of endpoints based on target organ development, the myriad modes of actions that need to be evaluated, and constraints due to the physical size of the animal (e.g. route of administration, necropsy techniques, blood collection, behavioral assessments, etc.)
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- The following data will be presented: body weights and body weight changes (pre- and post-weaning), pre-weaning reflex ontogeny, food consumption, motor activity (PNDs 59, 65, 80, 90, 96 and 124)
- Functional observational battery (PNDs 59, 80, 96 and 124), auditory startle habituation (PNDs 24, 60, 83, 97 and 125), learning and memory (Biel Maze; PNDs 60, 90, 84, 103 and 131), sexual maturation, estrous cyclicity and fertility.
- Estimated Blood Volumes for sampling based on age and body weight
- Clinical Pathology (clinical chemistry, haematology, coagulation and urinalysis)
