Modeling Cardiometabolic HFpEF with Translational Confidence
Heart failure with preserved ejection fraction (HFpEF) is one of the fastest-growing challenges in cardiovascular drug development, driven by overlapping obesity, hypertension, metabolic dysfunction, and renal impairment.
Many preclinical approaches fail to capture the complexity of cardiovascular-renal-metsbolic (CVRM) disease, contributing to translational gaps between preclinical findings and clinical outcomes.
The obese ZSF1 rat develops progressive cardiometabolic disease affecting CVRM systems simultaneously, allowing therapies to be evaluated within an integrated biological context. By capturing disease features across multiple physiological domains rather than single endpoints, the model supports comprehensive phenotyping and helps generate data that better inform preclinical CVRM drug discovery.
What You’ll Learn by Downloading the Poster
This scientific poster presents the characterization of the obese ZSF1 rat as a translational model of cardiometabolic HFpEF and outlines the study approach used to evaluate therapeutic response within a multi-organ disease setting.
By downloading the poster, readers can explore:
- How cardiometabolic disease features are assessed across CVRM systems in the obese ZSF1 rat
- The types of functional, biochemical, and molecular endpoints used to characterize HFpEF progression in a preclinical model
- How therapeutic intervention can be incorporated to help evaluate model translatability
- Considerations for studying interconnected CVRM pathology in preclinical drug discovery
- An example framework for integrating multi-system data in cardiometabolic research
Click here to download this scientific poster!
