NK cells are a highly relevant target for immunotherapy due to their strong ability to detect and kill cancer cells. While humanized mice strains like the NOD.SCID gamma have helped researchers advance many cancer therapies, they are not effective for studies targeting NK cells.
Bridging this research gap is the B-NDG hIL15 mouse, which features a B-NDG mouse background, yet also expresses the human IL15 cytokine.
Per study count and percentage data, B-NDG hIL15 mice outperformed B-NDG mice when it came to the viability and propagation of human NK cells over the 6-week study period. In addition, high levels of NK cells were maintained throughout this interim.
Complete the form to read our white paper, "Development, characterization, and validation of B-NDG hIL15 mice: A novel mouse strain expressing human IL15 on an ultra-immunodeficient B-NDG background."
